No, I actually haven't tried I-Drive left handed. Do you think it would be any more intuitive or user-friendly?

The computer desk I built at home I naturally built to accomodate my left mousing. But the layout of my desk at work lends itself more to right mousing.

Plus I find I suffer less wrist stress if I'm switching between hands. After extended gaming my left wrist can get a bit sore.

 

Im a righty so I have to ask, is it actually difficult to shift gears if you are left handed?

 

I'm left handed and never had a problem. When you learn how to shift it's with your right hand, from then on you really don't know any different.