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The IS wheels are tricky. Unlike your current wheels which have a et45, the IS rims have an ET of 50, and there we're two versions of the IS rims as well, they came in a 7" & 7.5" width adding to the problem
On the 3rd gen 97-01, you need a 10mm spacer to clear the rear struts, and knowing Lexus the rear struts on yours will be the only limitation.