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Lexus doesn't do much of that badge differentiation.
The IS250/350 look virtually identical.
The early SC300/400 had slightly different front facia's but they were the same after 97+.
450h can have avs, not the gs350.
450h can have the apsss, not the gs350.
450h can have the semi-aniline leather, not the gs350
450h has cvt, not the gs350
450h can have avs, not the gs350.
450h can have the apsss, not the gs350.
450h can have the semi-aniline leather, not the gs350
450h has cvt, not the gs350
i don't think you'll ever see a GS 300 / 350 with the radar cruise-pre-collision system or parking sensors. Even though they appear to be options, technically, I've never come across one.
The GS350's parking sensor is optional. It kind of a force option here in New England, every GS have them. Here in New England, the GS350 offer one of the best option that the GS460 doesnt not offer, AWD.