ljerryd

In 2017, we put 4500 miles on our 2007 in about 2 weeks of travel all over the Western US, from sea level to 10000 feet, Interstates to logging roads. Never a hiccup. Had about 125k on it at the time. When I bought it with 120k, I used the Lexus website to find one with the most up to date service records. Mine was a previous CPO with a hitch that never had been used. It still had the cable pigtails in the original bags in the rear storage. It was always a Texas car, so I didn't have to worry about corrosion issues. If you buy right, you will be happy to have "checked all your boxes"!

LoneHiker

Bought my '05 in 2016 with 130k. Now it has 190k and I drive it on 20+ hour trips all the time. Going on a 9 hour trip with it in a couple weeks. Never the slightest problem.

The only work I've had to do outside of routine maintenance is new CV axles and front wheel bearings when I first got it. Other than that it's been flawless.

nycbenz

These are amazing tourers! Plenty of space, and super comfortable, however gas mileage could be better.

Last year alone:
LA - Denver - LA
LA - Naples, FL - LA
LA - Naples, FL - LA

First two legs I had a cracked exhaust manifold, gas mileage was 13 on the highway lol. ****'s expensive to fix at the dealer.
Last leg my rear diff started going out when we reached Tampa, but she made it to Naples. ****'s really expensive to fix at the dealer lol (had to get the whole rearend assembly IIRC).

I also towed a trailer from NYC - LA, and it is such a great cross country tower. I love my truck, but after putting almost $10k in her last year, the wife is over it. I just hate electric-assist steering most new cars have now, and really love the "truckiness" feeling mine has after driving a loaner car from the dealer.

Lexus4321

My 2006 has been x-country 4x already, about 12kmi in total.
Never an issue, except a tad lighter in the wallet.