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not to worry about the high compression if the nitrous setup is right. I used to own a supercharged RSX which has an 11:1 compression and I know other people with the same setup run on 50 or 75 shots of nitrous without any problems. Tuning is the key IMO so there isn't any better or worse to run high compression engines with nitrous. Our engine already have an advantage of having high compression, after all people added boost to raise the compression and some will also add nitrous