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It is possible, however the controls on the 3IS steering wheel are not directly adaptable to the 2IS interface. In my opinion, if you're looking for a newer style steering wheel that should be a more direct fit, look to the CT200h.
Are you sure about the ct200h steering wheel Jeff or not?
Funnily enough, I recall reading Jeff's post about it years ago. He posted a little photoshop of it along with the pins and what they were for, some wiring and it'd work. The issue would be the cost of the airbag probably. https://www.clublexus.com/forums/is-...-in-is250.html