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It's not impossible to run the LS460 wheels. You can run adapters but it may not be worth spending the money on the adapter UNLESS you really like the LS460 wheels. In that case, go for it.
I've actually seen one before. It looks alright. You would need adapters to change the bolt pattern. To me it's worth it if you can find 460 wheels for cheap (common because they won't fit other Lexus models directly). I'll try to find the picture. GL!