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What size wheels and tires are you going to be running? Depends on offset and width and some other factors. LS430 wheel housing is big enough for 235/30R22 front, 285/25R22 rear, though I wouldn't go larger than 20's. Ride is going to suffer and its going to be expensive for tires etc. Heres some more info here: https://www.clublexus.com/forums/ls-...-an-ls430.html
There is no way they are going to fit 20's look more than enough for the ls430 22's are donk status
Like this camaro which I found for sale in albany NY
It's possible. I've seen guys do it but typically you have to roll/shave fenders. I think 22 inch wheels look fine on an LS430 if it's a nice style of wheel.
My advice would be to roll the fenders or you could look into pulling the fenders a bit. Don't go overly wide on wheels and tires and you should be fine.