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I have only 42,000 miles on my 07 LS460L and all were completely trouble free except for a blown audio amp at around 20,000 miles. I've driven from the Seattle area to Wisconsin twice, down through Texas, to the coast and back and a handful of trips to LA. I also have an 08 Rolls Royce Phantom I bought new and I still prefer driving my Lexus on long trips. I've recently been looking at a replacement and I've driven everything. I recently drove the new Continental GT and I still keep coming back to the Lexus. The only area where the car is now weak is in telematics side of the car. The GPS now seems outdated, compared to what's out there, and that's my biggest gripe, but feature for feature, I love the Lexus.
About to turn 116,000...I just do what the service manual says to do which includes changing the oil every 4,000 miles or so..I bought it 3 years ago with 22,000 miles...yes, I am a road lizard!
That is killer, mine is just turning 70k, but then I have had it for 15 months and it had over 60k when I bought it CPO. My next LS will be babied like Craigs!