Originally Posted by MysteryMob

The LS460 is more reliable than the other luxury cars in its class, but don't make the mistake of thinking this is a Camry or an IS350. There are MANY complex parts on these vehicles, all with high price tags, and the number of OE and aftermarket parts is very limited. Many things you can obtain at Autozone for other Lexus models at Autozone or Advance Auto are not even available, period.

As far as gas mileage, it depends on if you do more city or highway driving. On highway drives, I can get 30mpg going 78. But, this is a car that weighs over 4,000lbs with a naturally aspirated V8. The minute you start doing more city driving, that number gets dragged WAY down. My commute is split probably 60 highway 40 city, and I get about 19 mpg. My old commute was mainly city with some highway and I was getting around 16mpg.

The earlier versions had control arms that failed very quickly, dashboards and doorpanels that would melt like the IS, and brake actuators that can fail ($3,000 repair. $1,000+ if you DIY). If your trunk latch fails, those are over $600. The lifter motor for the trunk is about $1,000. It takes just under 9 quarts of oil. Front control arms are a wear item, due to the size of the vehicle, so you will need to factor that in to long-term ownership ($3,500 for OEM parts, $300 for the cheapest aftermarket, and probably $500 from Autozone). Tires don't last as long due to the weight, too.

So, don't buy one of these thinking you can just buy it and change the oils and tires. DIY can lower your cost, but it's still expensive and is going to require more to have than almost any of the other Lexus models.