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You'll have to be much more specific, and start by stating what car you have? SC300 or 400? Year? Auto or manual? Any mods? How long have you had it? What maintenance have you done to it? When did the problem start? Is the problem only there when engine is cold/hot/both? Have you done any diagnosis at all?
If it's a SC400, my guess would be ignition coils. Beyond that, there's not much point wasting time guessing until more details are provided, as emLEX said.
Seven years since registering and the first post, wow.